Weight Loss Goals

  • Wegovy vs Zepbound vs Mounjaro: What’s the Difference (and Which One Is Right for You?)

    So, you’re ready to start your GLP-1 journey — or you’ve been on one med and wondering, “Am I missing out on something better?” Enter: the comparison chaos. Wegovy, Zepbound, Mounjaro — they all sound like villain names from the Avengers, but they’re actually powerful tools helping thousands of people finally feel in control of their hunger, their weight, and their health.

    But what’s the difference between them? Does one work faster? Are the side effects worse on one? And most importantly — which one should you be on?

    Let’s break it down in plain English!


    Wegovy: The OG Weight Loss Game-Changer

    What it is:

    • Brand name for semaglutide
    • Originally developed for type 2 diabetes (as Ozempic), then repurposed for weight loss
    • Taken once weekly via injection

    Pros:

    • Well-researched and widely used
    • Proven to help with significant weight loss (up to 15% body weight in studies)
    • Often first choice in the UK and through NHS Tier 3 services
    • Known for its effect on appetite suppression and food noise reduction

    Considerations:

    • Common side effects: nausea, constipation, fatigue, and that lovely burping thing
    • Weight loss can plateau over time if habits don’t come along for the ride
    • Some people struggle with appetite loss so extreme, they forget to eat (which, FYI, isn’t the goal)

    Mounjaro: The Muscle-Friendly Metabolism Booster

    What it is:

    • Brand name for tirzepatide
    • Originally developed for type 2 diabetes (and still used for that)
    • Works on two hormones: GLP-1 and GIP — fancy, right?

    Pros:

    • Double hormone = potential stronger appetite control and better blood sugar regulation
    • Early studies suggest more fat loss and better muscle retention than semaglutide
    • Some people feel fewer side effects compared to Wegovy

    Considerations:

    • Not officially approved for weight loss in the UK (yet), though used off-label
    • May not be accessible through NHS services — mostly private clinics
    • Higher doses can hit harder, so titration is key (see: your burping, tired, slightly moody week 3)

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    Zepbound: The New Kid on the Fat-Loss Block

    What it is:

    • Brand name for tirzepatide officially approved for weight loss
    • Basically Mounjaro, but marketed specifically for fat loss rather than diabetes
    • Same active ingredient, different intention (and potentially, different insurance coverage if you’re in the US)

    Pros:

    • Approved for chronic weight management, not just diabetes
    • Strong appetite suppression and real reductions in food noise
    • Likely to become the go-to for people wanting to start with tirzepatide without a diabetes diagnosis

    Considerations:

    • Newer, so fewer long-term weight loss data sets than Wegovy
    • Like Mounjaro, it may come with a hefty price tag if you’re paying out of pocket
    • Some people feel more side effects during dose increases — nausea, tiredness, bloating

    So, Which One Is Right for You?

    Let’s make it easy.

    About Wegovy (Semaglutide) Mounjaro (Tirzepatide) Zepbound (Tirzepatide)
    Best for NHS access, first-timers, strong appetite suppression Muscle retention, PCOS, insulin resistance, private care New starters wanting a weight-loss–focused tirzepatide
    Side effects Mild to moderate nausea, fatigue, constipation Can be gentler for some, but depends on dose Similar to Mounjaro, may be more intense at higher doses
    Access in UK NHS + private Private clinics only (off-label for weight loss) Not currently available in UK
    Access in US Prescription with insurance (often needs pre-auth); self-pay available Prescription with or without insurance (for diabetes); often used off-label for weight loss Prescription approved for weight loss; available with insurance or self-pay
    Effectiveness Up to 15% body weight loss Up to 20% in some studies Same as Mounjaro — potential for higher fat loss, less muscle loss
    Cost (Private) UK: £150–£250/month
    US: $1,000–$1,300/month (full price); may be lower with insurance or savings card
    UK: £200–£300+/month (private)
    US: $1,000–$1,300/month; some discounts with insurance or coupons
    UK: Not yet available
    US: $1,000–$1,300/month; covered by some insurers for weight loss

    Bottom Line: They’re All Tools — Not Magic

    Here’s the truth: Wegovy, Zepbound or Mounjaro? None of these meds are a cheat code.

    But they are powerful tools to help you:

    • Regulate hunger
    • Reduce emotional eating
    • Break out of binge–restrict cycles
    • Stay consistent with a high-protein GLP-1 meal plan
    • Feel stronger, healthier, and more in control

    The difference between Wegovy, Zepbound or Mounjaro will come down to:

    • How your body responds
    • What’s accessible to you (hello, budget and location)
    • And how well you support it with things like meal planning, movement, and mindset

    Next Steps:

    Still not sure which one is right for you?

    Whatever med you’re on — or thinking about — you’re not behind, you’re not broken, and you’re definitely not alone.


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